Methionine ligand selectively promotes monofunctional adducts between trans-EE platinum anticancer drug and guanine DNA base.
نویسندگان
چکیده
A detailed study on the reaction mechanism of trans-EE and trans-EE/Met Pt-containing anticancer drugs was carried out in order to rationalize the experimental kinetic data concerning the whole process leading to DNA platination.
منابع مشابه
DNA adducts of antitumor trans-[PtCl2 (E-imino ether)2].
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متن کاملThioether binding mediates monofunctional platinum antitumor reagents to trans configuration in DNA interactions.
Methionine binding converts monofunctional platinum antitumor agents to trans configuration adducts in the reaction with DNA, which suggests the correlation of two classes of platinum complexes in the antitumor mechanism.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 3 شماره
صفحات -
تاریخ انتشار 2011